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Association analyses identify six new psoriasis susceptibility loci in the Chinese population 期刊论文

编号：

60BEAACE7E2F08A08CC68FB02E068B63
作者：

Sun, LiangDan#^[1,2,3,4]Cheng, Hui#^[1,2,3,4]Wang, ZaiXing#^[1,2,3,4]Zhang, AnPing#^[1,2,3,4]Wang, PeiGuang#^[1,2,3,4]Xu, JinHua^[5];Zhu, QiXing^[1,2,3,4];Zhou, HaiSheng^[4,6];Ellinghaus, Eva^[7];Zhang, FuRen^[3,8];Pu, XiongMing^[3,9];Yang, XueQin^[3,10];Zhang, JianZhong^[11];Xu, AiE^[3,12];Wu, RiNa^[13];Xu, LiMin(徐丽敏)^[14]Peng, Lin^[15];Helms, Cynthia A.^[15];Ren, YunQing^[1,2,3,4];Zhang, Chi^[1,2,3,4];Zhang, ShuMei^[1,2,4];Nair, Rajan P.^[16];Wang, HongYan^[1,2,3,4];Lin, GuoShu^[1,2,3,4];Stuart, Philip E.^[16];Fan, Xing^[1,2,3,4];Chen, Gang^[3,4];Tejasvi, Trilokraj^[16];Li, Pan^[1,2,3,4];Zhu, Jun^[1,2,3,4];Li, ZhiMing^[1,2,3,4];Ge, HongMei^[1,2,3,4];Weichenthal, Michael^[17];Ye, WenZheng^[1,2,3,4];Zhang, Cheng^[1,2,3,4];Shen, SongKe^[1,2,3,4];Yang, BaoQi^[8];Sun, YuanYuan^[1,2,3,4];Li, ShanShan^[1,2,3,4];Lin, Yan^[1,2,3,4];Jiang, JianHua^[9];Li, CunTao^[1,2,3,4];Chen, RiXin^[1,2,3,4];Cheng, Juan^[10];Jiang, Xin^[1,2,3,4];Zhang, Peng^[1,2,3,4];Song, WeiMin^[12];Tang, Jin^[1,2,3,4];Zhang, HaoQin^[1,2,3,4];Sun, Li;Cui, Jing^[1,2,3,4];Zhang, LiJun^[1,2,3,4];Tang, Biao^[1,2,3,4];Huang, Fei^[1,2,3,4];Qin, Qian^[1,2,3,4];Pei, XiaoPing^[1,2,3,4];Zhou, AiMin(周爱民)^[14]Shao, LiMei^[1,2,3,4];Liu, JianLan^[1,2,3,4];Zhang, FengYu^[1,2,4];Du, WeiDong^[1,2,4];Franke, Andre^[7];Bowcock, Anne M.^[15];Elder, James T.^[16];Liu, JianJun^[1,2,4,18];Yang, Sen^[1,2,3,4];Zhang, XueJun*^[1,2,3,4,5]
语种：

英文
期刊：

NATURE GENETICS ISSN：1061-4036 2010 年 42 卷 11 期 (1005 - U132) ; NOV
收录：
摘要：

We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 x 10(-8)) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 x 10(-21)) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 x 10(-3) and P = 7.9 x 10(-3), respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 x 10(-3) and P = 1.5 x 10(-3), respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.
推荐引用方式
GB/T 7714：

Sun Liang-Dan,Cheng Hui,Wang Zai-Xing, et al. Association analyses identify six new psoriasis susceptibility loci in the Chinese population [J].NATURE GENETICS,2010,42(11):1005-U132.
APA：

Sun Liang-Dan,Cheng Hui,Wang Zai-Xing,Zhang An-Ping,&Zhang Xue-Jun.(2010).Association analyses identify six new psoriasis susceptibility loci in the Chinese population .NATURE GENETICS,42(11):1005-U132.
MLA：

Sun Liang-Dan, et al. "Association analyses identify six new psoriasis susceptibility loci in the Chinese population" .NATURE GENETICS 42,11(2010):1005-U132.
学科相关词得分：

Asian Continental Ancestry Group (亚洲大陆世系人群) 

Psoriasis (银屑病) 

Population (人口) 

Association (联想) 

Genome-Wide Association Study (全基因组关联研究) 

Nuclear Family (核型家庭) 

Genes (基因) 

Genetic Predisposition to Disease (疾病遗传易感性) 

United States (美国) 

Disease (疾病) 

Germany (德国) 

Disease Susceptibility (疾病易感性) 

Family (家庭) 

China (中国) 

Genome (基因组) 
入库时间：

7/7/2022 2:20:25 PM
更新时间：

7/7/2022 2:20:25 PM
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