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Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy 期刊论文 WOS高被引论文

编号：

C64B30AAA6A81B3729965409EBEC03EF
作者：

Meng, Xuan#^[1,2]Deng, Jian^[1,2];Liu, Fang^[1,2];Guo, Tao(郭涛)^[3]Liu, Mengying^[1,2];Dai, Peipei^[1,2];Fan, Aiping^[1,2];Wang, Zheng^[1,2];Zhao, Yanjun*^[1,2]
语种：

英文
期刊：

NANO LETTERS ISSN：1530-6984 2019 年 19 卷 11 期 (7866 - 7876) ; NOV
收录：
关键词：

Photodynamic therapy ferroptosis redox-responsive drug delivery metal organic framework
摘要：

Nanoscale photodynamic therapy (PDT) is an appealing antitumor modality for which apoptosis is the major mechanism of toxicity induction. It was postulated that the highly reactive singlet oxygen in PDT could deplete glutathione (GSH) and activate ferroptosis, the extent to which could be further manipulated by a redox-responsive nanocarrier. To validate this, a disulfide-bearing imidazole ligand coordinated with zinc to form an all-active metal organic framework (MOF) nanocarrier where a photosensitizer (chlorin e6/Ce6) was encapsulated. Regardless of light irradiation, the Ce6-loaded nanocarrier caused the depletion of intracellular GSH via the disulfide-thiol exchange reaction in a murine mammary carcinoma cell line (4T1). The GSH depletion further caused the inactivation of glutathione peroxide 4 (GPX4) and the enhancement of cytotoxicity that was alleviated by ferroptosis inhibitors. The superior in vivo antitumor efficacy of the all-active nanocarrier was corroborated in a 4T1 tumor-bearing mice model regarding tumor growth suppression and animal survival rate. The coadministration of an iron chelator weakened the antitumor potency of the nanocarrier due to ferroptosis inhibition, which was supported by the fact of tumor growth upsurge and the recovered GPX4 activity. The current work highlights the contribution of ferroptotic machinery to antitumor PDT via an activatable, adaptable, all-active MOF nanocarrier.
推荐引用方式
GB/T 7714：

Meng Xuan,Deng Jian,Liu Fang, et al. Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy [J].NANO LETTERS,2019,19(11):7866-7876.
APA：

Meng Xuan,Deng Jian,Liu Fang,Guo Tao,&Zhao Yanjun.(2019).Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy .NANO LETTERS,19(11):7866-7876.
MLA：

Meng Xuan, et al. "Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy" .NANO LETTERS 19,11(2019):7866-7876.
学科相关词得分：

Ferroptosis (NULL) 

Therapeutics (治疗学,治疗法,治疗) 

Light (光) 

Survival Rate (存活率) 

Oxygen (氧) 

Singlet Oxygen (单态氧) 

Neoplasms (肿瘤) 

Cells (细胞) 

Oxidation-Reduction (氧化还原) 

Iron (铁) 

Zinc (锌) 

Survival (幸存) 

Mice (小鼠) 

Animals (动物) 

Apoptosis (细胞凋亡) 

Cell Line (细胞系) 

Form (NULL) 

Glutathione (谷胱甘肽) 

Growth (生长) 

Carcinoma (癌) 

Work (工作) 
入库时间：

6/27/2022 12:22:55 PM
更新时间：

6/27/2022 12:22:55 PM

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