This study aimed to optimize an injectable carbonated hydroxyapatite cement for metaphyseal bone defect filling and to evaluate its biomechanical performance in distal radius fracture fixation. Six food- or pharmaceutical-grade additives, including sodium alginate, glycerol, astragalus gum, xanthan gum, citric acid, and hydroxypropyl methylcellulose (HPMC), were screened to improve injectability while maintaining setting behavior and mechanical strength. Among them, 2% HPMC provided the best overall performance, increasing injectability to approximately 95% without markedly affecting setting time or compressive strength. The optimized injectable carbonated hydroxyapatite cement (ICHA) was then tested in a standardized human cadaveric distal radius fracture-defect model using three fixation strategies: K-wire fixation alone, ICHA cement alone, and combined ICHA + K-wire fixation. Within a 10 degrees torsion range, the ICHA and ICHA + K-wire groups showed higher torsional stiffness and maximum torque than the K-wire-only group, although peak torque occurred at smaller torsion angles. Under physiological compression, the groups showed comparable stability, whereas ICHA-containing groups showed greater resistance under higher compression. These findings suggest that 2% HPMC-modified ICHA may serve as an injectable metaphyseal void filler and structural adjunct to conventional K-wire fixation.
[1]Tianjin Ctr Dis Control & Prevent, Dept Toxicol, 6 Huayue Rd, Tianjin 300011, Peoples R China.
[2]NHC Specialty Lab Food Safety Risk Assessment & St, 6 Huayue Rd, Tianjin 300011, Peoples R China.
[3]Tianjin Acad Tradit Chinese Med, Dept Orthoped Surg, Affiliated Hosp, 354 Beima Rd, Tianjin 300120, Peoples R China.
[4]Tianjin Univ, Tianjin Hosp, Dept Spine Surg, 406 Jiefang South Rd, Tianjin 300211, Peoples R China.
(8.0+极速模式)